Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

The type 2 cannabinoid receptor (CB2R) was initially regarded as a peripheral cannabinoid
receptor. However, recent technological advances in gene detection, alongside the …

Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

Microglia are resident immune cells of the brain that survey the microenvironment, provide
trophic support to neurons, and clear debris to maintain homeostasis and healthy brain …

Chronic pain is a complex sensory, cognitive, and emotional experience that imposes a
great personal, psychological, and socioeconomic burden on patients. An estimated 1.5 …

Despite its essential role in the (patho) physiology of several diseases, CB2R tissue
expression profiles and signaling mechanisms are not yet fully understood. We report the …

Background and Purpose Endocannabinoids are critically involved in brain reward
functions, mediated by activation of CB1 receptors, reflecting their high density in the brain …

Cannabis sativa, is also popularly known as marijuana, has been cultivated and used for
recreational and medicinal purposes for many centuries. The main psychoactive content in …

We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands
with a tailored functional response. The present study discloses the structure-based design …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …