Activation of microglia and astrocytes secondary to inflammatory processes contributes to
the development and perpetuation of pain with a neuropathic phenotype. This pain state …

Diabetic neuropathy is a chronic complication to metabolic disorder, diabetes mellitus. Till
date, diagnosis and treatment of diabetic neuropathy remain elusive with challenges …

Nerve injury is associated with microvascular disturbance; however, the role of the vascular
system has not been well characterized in the context of neuropathic pain. Furthermore …

The blood-nerve barrier (BNB) is a selectively permeable barrier that creates an
immunologically and biochemically privileged space for peripheral axons and supporting …

Background Cardiovascular diseases are among the most important causes of morbidity
and mortality in the world. One of the important risk factors of cardiovascular disease is …

Spinal glial and proinflammatory cytokine actions are strongly implicated in pathological
pain. Spinal administration of the anti-inflammatory cytokine interleukin (IL)-10 abolishes …

Introduction: Statins remain among the most frequently prescribed drugs and constitute a
cornerstone in the prevention of cardiovascular disease. However, muscle symptoms are …

Simvastatin, an inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase, is invariably
used to treat cardiovascular diseases. Simvastatin has been recently demonstrated to have …

Atorvastatin is an HMG-CoA reductase inhibitor used in the treatment of
hypercholesterolemia and prevention of coronary heart disease. Oxidative stress is …

Treating peripheral nerve defects represents a clinical challenge, and nerve conduits
lacking an internal scaffold lead to limited large nerve gap regeneration. Here, we bridged …