Cell therapy involves the transplantation of human cells to replace or repair the damaged
tissues and modulate the mechanisms underlying disease initiation and progression in the …

Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease caused by the destruction of
pancreatic β‐cells in response to autoimmune reactions. Shapiro et al. conducted novel islet …

Type 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of β-cells
in the pancreatic islets. In this regard, islet transplantation aims for the replacement of the …

Pancreatic islet transplantation provides an effective treatment option for patients with type 1
diabetes (T1D) with intractable impaired awareness of hypoglycemia and severe …

Diabetes has become one of the largest global health and economic burdens, with its
increased prevalence and high complication ratio. Stable and satisfactory blood glucose …

This review will detail the current status of islet xenotransplantation as a potential treatment
for type I diabetes mellitus, focusing on recent advances in porcine xenogeneic islet …

The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …

Abstract Purpose of Review Porcine islets represent a potentially attractive beta-cell source
for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo …

Islet transplantation can restore lost glycemic control in type 1 diabetes subjects but is
restricted in its clinical application by a limiting supply of islets and the need for heavy …

Background. Results in murine and nonhuman primate suggested that the bone marrow
(BM) might be an alternative site for pancreatic islet transplantation. Methods. We report the …