Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Context: Secondary amenorrhea—the absence of menses for three consecutive cycles—
affects approximately 3–4% of reproductive age women, and infertility—the failure to …

Adrenal insufficiency is caused by either primary adrenal failure (mostly due to autoimmune
adrenalitis) or by hypothalamic-pituitary impairment of the corticotropic axis (predominantly …

This review summarises the key clinical features of septo-optic dysplasia (SOD), the
significant inroads that progress in genetics has made into our understanding of the …

Abstract PHACE (OMIM no. 606519) is a neurocutaneous syndrome that refers to the
association of large, plaque‐like,“segmental” hemangiomas of the face, with one or more of …

The development of the corpus callosum depends on a large number of different cellular
and molecular mechanisms. These include the formation of midline glial populations, and …

Duplications of Xq26-27 have been implicated in the etiology of X-linked hypopituitarism
associated with mental retardation (MR). Additionally, an expansion of a polyalanine tract …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …