Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1
(105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to …

Meats cooked at high temperatures, such as pan-frying or grilling, are a source of
carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively …

Organochlorine pesticides (OCPs) and polymorphisms of xenobiotic metabolizing enzymes
are reported to be associated with the possible risk of prostate cancer. OCPs are endocrine …

American men have a lifetime risk of about 18% for prostate cancer diagnosis. Large
international variations in prostate cancer risks and increased risks among migrants from …

Background and Objectives The GSTM1, GSTT1 and GSTP1 polymorphisms might be
involved in inactivation of procarcinogens that contribute to the genesis and progression of …

Androgens are traditionally recognized as the major hormone promoting normal and
aberrant growth of the prostate. However, recent literature suggests that estrogen could also …

Genetic differences in the metabolism of xenobiotics have recently been suggested as
modifiers of individual susceptibility to bladder cancer (BC). The objective of this study was …

Objective: Prostate cancer (PCa) is a major public health problem worldwide, with high
morbidity and mortality levels. Advanced age, androgen stimulation, and ethnicity have been …

Endocrine disrupting chemicals disrupt normal physiological function of endogenous
hormones, their receptors, and signaling pathways of the endocrine system. Most endocrine …