Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Inflammasome activation at the crux of severe COVID-19

SM Vora, J Lieberman, H Wu - Nature Reviews Immunology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

N Murgolo, AG Therien, B Howell, D Klein… - Advances in Clinical …, 2021 - taylorfrancis.com
Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …

Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19

RK Thimmulappa, KK Mudnakudu-Nagaraju… - Heliyon, 2021 - cell.com
Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …

[HTML][HTML] SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

C Junqueira, Â Crespo, S Ranjbar… - Research …, 2021 - ncbi.nlm.nih.gov
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

Association of vitamin D status with COVID-19 and its severity: Vitamin D and COVID-19: A narrative review

JH Bae, HJ Choe, MF Holick, S Lim - Reviews in Endocrine and Metabolic …, 2022 - Springer
Vitamin D is associated with biological activities of the innate and adaptive immune systems,
as well as inflammation. In observational studies, an inverse relationship has been found …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19

Y Zhang, M Juhas, CK Kwok - Trends in Biotechnology, 2023 - cell.com
SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global
mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies …