Preventing fibrosis in IBD: update on immune pathways and clinical strategies

J Wang, B Yang, J Chandra, A Ivanov… - Expert Review of …, 2024 - Taylor & Francis
Introduction Intestinal fibrosis is a common and serious complication of inflammatory bowel
diseases (IBD) driving stricture formation in Crohn's disease patients and leading to …

Intestinal strictures in Crohn's disease: An update from 2023

Z Liu, Z Huang, Y Wang, S Xiong, S Lin… - United European …, 2024 - Wiley Online Library
Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in
nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of …

[HTML][HTML] Evaluation of the Antifibrotic Effects of Drugs Commonly Used in Inflammatory Intestinal Diseases on In Vitro Intestinal Cellular Models

S Artone, A Ciafarone, FR Augello… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The mechanism underlying intestinal fibrosis, the main complication of inflammatory bowel
disease (IBD), is not yet fully understood, and there is no therapy to prevent or reverse …

Non-coding transcribed ultraconserved region uc. 290 in colon mucosa promotes intestinal fibrosis in chronic active ulcerative colitis

XX Qian - Digestive and Liver Disease, 2024 - Elsevier
Background and aims TGF-β1 induces epithelial-mesenchymal transition (EMT) and leads
to intestinal fibrosis in ulcerative colitis (UC). We aimed to investigate the expression of …