NAD+ metabolism and its roles in cellular processes during ageing

AJ Covarrubias, R Perrone, A Grozio… - Nature reviews Molecular …, 2021 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

NAD+ homeostasis in health and disease

E Katsyuba, M Romani, D Hofer, J Auwerx - Nature metabolism, 2020 - nature.com
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

The multifaceted contributions of mitochondria to cellular metabolism

JB Spinelli, MC Haigis - Nature cell biology, 2018 - nature.com
Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

SLC25A51 is a mammalian mitochondrial NAD+ transporter

TS Luongo, JM Eller, MJ Lu, M Niere, F Raith, C Perry… - Nature, 2020 - nature.com
Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the
fundamental processes that fuel respiration and mediate cellular energy transduction …

Therapeutic potential of NAD-boosting molecules: the in vivo evidence

L Rajman, K Chwalek, DA Sinclair - Cell metabolism, 2018 - cell.com
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

NAD+ in brain aging and neurodegenerative disorders

S Lautrup, DA Sinclair, MP Mattson, EF Fang - Cell metabolism, 2019 - cell.com
NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …

[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways

S Amjad, S Nisar, AA Bhat, MP Frenneaux, K Fakhro… - Molecular …, 2021 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Fasting and cancer: molecular mechanisms and clinical application

A Nencioni, I Caffa, S Cortellino, VD Longo - Nature Reviews Cancer, 2018 - nature.com
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …