Can we engineer a human cardiac patch for therapy?

J Zhang, W Zhu, M Radisic… - Circulation …, 2018 - Am Heart Assoc
Some of the most significant leaps in the history of modern civilization—the development of
article in China, the steam engine, which led to the European industrial revolution, and the …

Cell therapy in patients with heart failure: a comprehensive review and emerging concepts

R Bolli, M Solankhi, XL Tang… - Cardiovascular research, 2022 - academic.oup.com
This review summarizes the results of clinical trials of cell therapy in patients with heart
failure (HF). In contrast to acute myocardial infarction (where results have been consistently …

Embedded spheroids as models of the cancer microenvironment

KM Tevis, YL Colson, MW Grinstaff - Advanced biosystems, 2017 - Wiley Online Library
To more accurately study the complex mechanisms behind cancer invasion, progression,
and response to treatment, researchers require models that replicate both the multicellular …

The application of umbilical cord‐derived MSCs in cardiovascular diseases

Y Chen, H Shen, Y Ding, Y Yu, L Shao… - Journal of Cellular and …, 2021 - Wiley Online Library
Transplantation of stem cells is a promising, emerging treatment for cardiovascular diseases
in the modern era. Mesenchymal stem cells (MSCs) derived from the umbilical cord are one …

MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease

EC Martinez, S Lilyanna, P Wang, LA Vardy… - Journal of molecular and …, 2017 - Elsevier
Rationale Myocardial infarction (MI) triggers a dynamic microRNA response with the
potential of yielding therapeutic targets. Objective We aimed to identify novel aberrantly …

Microtissues in cardiovascular medicine: regenerative potential based on a 3D microenvironment

J Günter, P Wolint, A Bopp, J Steiger… - Stem cells …, 2016 - Wiley Online Library
More people die annually from cardiovascular diseases than from any other cause. In
particular, patients who suffer from myocardial infarction may be affected by ongoing …

Concise review: fetal membranes in regenerative medicine: new tricks from an old dog?

R Lim - Stem Cells Translational Medicine, 2017 - academic.oup.com
The clinical application of the fetal membranes dates back to nearly a century. Their use has
ranged from superficial skin dressings to surgical wound closure. The applications of the …

GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia

S Lilyanna, MT Peh, OW Liew, P Wang… - Journal of molecular and …, 2015 - Elsevier
Aims Myocardial infarction followed by adverse left ventricular (LV) remodeling is the most
frequent proximate cause of heart failure. Hydrogen sulfide (H 2 S) is an important …

Filling the gaps between the in vivo and in vitro microenvironment: engineering of spheroids for stem cell technology

C Gentile - Current stem cell research & therapy, 2016 - ingentaconnect.com
Engineering of in vitro three-dimensional cultures of stem cells and their progenies has
offered promising alternatives to recapitulate the in vivo microenvironment, or stem cell …

Functional augmentation of naturally-derived materials for tissue regeneration

AB Allen, LB Priddy, MTA Li, RE Guldberg - Annals of biomedical …, 2015 - Springer
Tissue engineering strategies have utilized a wide spectrum of synthetic and naturally-
derived scaffold materials. Synthetic scaffolds are better defined and offer the ability to …