The versatility of RNA in sensing and interacting with small molecules, proteins and other
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

Programmable approaches to sense and respond to the presence of specific RNAs in
biological systems have broad applications in research, diagnostics, and therapeutics. Here …

Engineered RNA elements are programmable tools capable of detecting small molecules,
proteins, and nucleic acids. Predicting the behavior of these synthetic biology components …

The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells
would facilitate a variety of biotechnological applications. Current strategies are limited by …

While synthetic biology has revolutionized our approaches to medicine, agriculture, and
energy, the design of completely novel biological circuit components beyond naturally …

Applications of RNA-based molecular logic have been hampered by sequence constraints
imposed on the input and output of the circuits. Here we show that the sequence constraints …

The ability to identify single-nucleotide mutations is critical for probing cell biology and for
precise detection of disease. However, the small differences in hybridization energy …

Toehold-mediated strand displacement (TMSD) reactions between double-stranded DNA
and single-stranded oligonucleotides, which use a toehold structure as a switch, enable …

Molecular communication (MC) engineering is inspired by the use of chemical signals as
information carriers in cell biology. The biological nature of chemical signaling makes MC a …