So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

The aging human population with age-associated diseases has become a problem
worldwide. By 2050, the global population of those who are aged 65 years and older will …

Adolescent binge drinking increases Toll-like receptor 4 (TLR4), receptor for advanced
glycation end products (RAGE), the endogenous TLR4/RAGE agonist high-mobility group …

The locus coeruleus (LC), our main source of norepinephrine (NE) in the brain, declines with
age and is a potential epicentre of protein pathologies in neurodegenerative diseases (ND) …

Leukotrienes, a class of inflammatory bioactive lipids, are well studied in the periphery, but
less is known of their importance in the brain. We identified that the enzyme leukotriene A4 …

Neural interfaces, emerging at the intersection of neurotechnology and urban planning,
promise to transform how we interact with our surroundings and communicate. By recording …

Fatty acids are key components in the structural diversity of lipids and play a strategic role in
the functional properties of lipids which determine the integrity of neuronal and glial cell …

Ageing is characterized by a gradual decline in the efficiency of physiological functions and
increased vulnerability to diseases. Ageing affects the entire body, including physical …

OBJECTIVE Severe hypoglycemia is associated with an increased risk of dementia. We
examined if the association is consistently present in mid-and late-life hypoglycemia …

Neurons live a lifetime. Neuronal aging may increase the risk of Alzheimer's disease. How
does neuronal membrane trafficking maintain synapse function during aging? In the normal …