Amide synthesis is one of the most widely practiced chemical reactions, owing to its use in
drug development and peptide synthesis. Despite the importance of these applications, the …

Despite the rapid growth of enantioselective halolactonization reactions in recent years,
most are effective only when forming smaller (6, 5, 4-membered) rings. Seven-membered ε …

A one-pot protocol for the synthesis of 5-(1, 2, 3, 4-tetrahydroisoquinolin-1-yl)-1, 3, 4-
oxadiazoles via DEAD-mediated oxidative Ugi/aza-Wittig reaction has been developed. The …

Conventional amide synthesis is a mainstay in discipline-spanning applications, and it is a
reaction type that historically developed as a singular paradigm when considering the …

Various five-membered N-heterocycles, such as oxadiazoles, thiadiazoles, oxazolines and
imidazoles, were prepared in one pot via electrochemical oxidation/[4+ 1] cyclization …

A stereocontrolled synthesis of β2, 3-amino amides is reported. Innovation is encapsulated
by the first use of nitroalkenes to achieve double umpolung in enantioselective β-amino …

4-Hydrazinylpyrazolo [1, 5-а] pyrazines were obtained by reactions of 4-chloropyrazolo [1, 5-
а] pyrazines with hydrazine hydrate and further combined with compounds having one …

Condensation of aminoazoles with (2 E)-(3-morpholin-4-yl) acrylonitrile and 3, 3-
diethoxypropionitrile was used to synthesize a series of azolo [1, 5-a] pyrimidin-7-amines. It …

Umpolung amide synthesis (UmAS) exploits the unique properties of an α-halo nitroalkane
in its reaction with an amine to produce an amide. The “umpolung” moniker reflects its …

Дисертаційна робота присвячена розробленню препаративно зручних та ефективних
методів синтезу нових функціоналізованих та гетероанельованих піразоло [1, 5-a] …