Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the
pain experience persists after the painful stimulus has resolved. The efficacy of current …

Background One of the sources of knee pain in osteoarthritis (OA) is believed to be related
to local chronic inflammation of the knee joints, which involves the production of …

Background The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear,
whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We …

Neuropathic pain after peripheral nerve injury, associated with local neuroinflammation in
the spinal cord, is a severe incapacitating condition with which clinical treatment remains …

In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …

Sciatic nerve injury has been used for over a century to investigate the process of nerve
damage, to assess the absolute and relative capacity of the central and peripheral nervous …

Neuroinflammation is one of the most significant pathological drivers following nerve injury
which along with immune cell activation, oxidative stress and other associated molecular …

Systemic injection of lipopolysaccharide (LPS) induces a robust immune response as well
as thermal and mechanical hyperalgesia. Spinal and peripheral glial cells have been …

Our previous works have shown that pro-inflammatory cytokine tumor necrosis factor-alpha
(TNF-α) plays an important role in neuropathic pain produced by lumber 5 ventral root …