Current and emerging therapies for corneal neovascularization

D Roshandel, M Eslani, A Baradaran-Rafii… - The ocular …, 2018 - Elsevier
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …

An update on chemical eye burns

M Bizrah, A Yusuf, S Ahmad - Eye, 2019 - nature.com
Ocular chemical injuries vary in severity, with the more severe end of the spectrum having
profound visual consequences and medicolegal implications. Grading of ocular injuries is …

Global consensus on the management of limbal stem cell deficiency

SX Deng, F Kruse, JAP Gomes, CC Chan, S Daya… - Cornea, 2020 - journals.lww.com
Purpose: In recent decades, the medical and surgical treatment of limbal stem cell deficiency
(LSCD) has evolved significantly through the incorporation of innovative pharmacological …

[HTML][HTML] Up-to-date molecular medicine strategies for management of ocular surface neovascularization

Y Yang, J Zhong, D Cui, LD Jensen - Advanced Drug Delivery Reviews, 2023 - Elsevier
Ocular surface neovascularization and its resulting pathological changes significantly alter
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …

Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review

JV Cabral, CJ Jackson, TP Utheim, K Jirsova - Stem Cell Research & …, 2020 - Springer
Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or
bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first …

The progress in corneal translational medicine

Z Hancox, SH Keshel, S Yousaf, M Saeinasab… - Biomaterials …, 2020 - pubs.rsc.org
Cornea tissue is in high demand by tissue donation centres globally, and thus tissue
engineering cornea, which is the main topic of corneal translational medicine, can serve as …

Clinical trials of limbal stem cell deficiency treated with oral mucosal epithelial cells

J Oliva, F Bardag-Gorce, Y Niihara - International Journal of Molecular …, 2020 - mdpi.com
The corneal surface is an essential organ necessary for vision, and its clarity must be
maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus …

Diagnostic algorithm for surgical management of limbal stem cell deficiency

B Malyugin, S Kalinnikova, R Isabekov, D Ostrovskiy… - Diagnostics, 2023 - mdpi.com
Background: Limbal stem cell deficiency (LCSD) presents several challenges. Currently,
there is no clearly defined systematic approach to LSCD diagnosis that may guide surgical …

Clinical studies of COMET for total LSCD: a review of the methods and molecular markers for follow-up characterizations

E Attico, G Galaverni, G Pellegrini - Current Ophthalmology Reports, 2021 - Springer
Abstract Purpose of Review This review outlines the main features of the clinical trials where
cultivated oral mucosa epithelial cell transplantation (COMET) was performed, aiming to …

Outcomes of Combined Penetrating Keratoplasty and Limbal Stem Cell Transplantation: A Meta-Analysis on Simultaneous Versus Sequential Surgery

I Giachos, CD Angelidis, S Doumazos, C Tzavara… - Cornea, 2023 - journals.lww.com
Purpose: The objective of this study is to perform a systematic review and meta-analysis of
the published studies on limbal stem cell transplantation (LSCT) combined with penetrating …