The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …

Rationale: Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene
expression program that allows them to fire automatically and initiate the heartbeat …

Human pluripotent stem cells (hPSCs) offer a multifaceted platform to study cardiac
developmental biology, understand disease mechanisms, and develop novel therapies …

The rate of contraction of the heart relies on proper development and function of the
sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3+ …

Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA)
in animals remain challenging. Here, using multiple knockout mouse models and single cell …

Cardiac biological pacing (BP) is one of the future directions for bradyarrhythmias
intervention. Currently, cardiac pacemaker cells (PCs) used for cardiac BP are mainly …

The rhythmic contraction of the heart is initiated and controlled by an intrinsic pacemaker
system. Cardiac contractions commence at very early embryonic stages and coordination …

The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …

Development of specialized cells and structures in the heart is regulated by spatially-
restricted molecular pathways. Disruptions in these pathways can cause severe congenital …