Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Evidence from neuropathological, genetic, animal model, and biochemical studies has
indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably …

Neural plasticity plays a critical role in mediating short‐and long‐term brain responses to
environmental stimuli. A major effector of plasticity throughout many regions of the brain is …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

The molecular mechanisms underlying plastic changes in the strength and connectivity of
excitatory synapses have been studied extensively for the past few decades and remain the …

The accumulation of soluble amyloid-β (Aβ) peptides produces profound neuronal changes
in the brain during the pathogenesis of Alzheimer's disease. Excessive levels of Aβ disrupt …

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the
production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor …

The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information
processing in the brain, and ubiquitination is a key regulator for this biological process …

One of the most intriguing features of the brain is its ability to be malleable, allowing it to
adapt continually to changes in the environment. Specific neuronal activity patterns drive …

Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic
proteins. While much has been learned on synaptic protein synthesis, little is known on the …