Drug delivery across cellular barriers, such as intestinal, nasal, buccal, alveolar, vaginal,
ocular and blood–brain, is a challenging task. Multiple physiological mechanisms, such as …

Studies the rectal membrane are interesting for biochemical research as well as providing a
basis for the development of new formulations of poorly absorbed drugs such as some …

Fenoterol HBr is a bronchodilator known to be subject to first pass effect after oral
administration. The aim of this study was to prepare and evaluate fenoterol HBr …

The aim of this work was to develop the best formulations for naproxen suppositories. The
effects of different bases and surfactants on the physicochemical characteristics of the …

The addition of surfactants to suppository formulations is referred to in the scientific literature,
but their effects on drug availability remain uncertain. Surfactants are reported to improve …

Piroxicam is an effective anti-inflammatory agent; it is an inhibitor of prostaglandin
biosynthesis. The Principal advantage of prioxicam is its long half-life, which permits the …

Preparation and in vitro evaluation of suppositories of halofantrine hydrochloride Page 1
African Journal of Biotechnology Vol. 5 (19), pp. 1775-1780, 2 October 2006 Available …

Physical and Release Properties of Metronidazole Suppositories Page 1 Erah & Chuks-Eboka
Trop J Pharm Res, March 2008; 7 (1) 887 Tropical Journal of Pharmaceutical Research …

Ketotifen KT is one of antiallergic drugs, due to its first pass effect, the bioavailability of the
drug is only 50%. The objective of this study was to formulate and evaluate suppositories …

A review has been supposed to be arranged on the literature published between 1996 and
2018 concerning applications of suppositories in clinical practice. The rectal route of drug …