The microcirculation: a key player in obesity-associated cardiovascular disease

O Sorop, TD Olver, J van de Wouw… - Cardiovascular …, 2017 - academic.oup.com
It is increasingly recognized that obesity is a risk factor for microvascular disease, involving
both structural and functional changes in the microvasculature. This review aims to describe …

Capillary Rarefaction in Obesity and Metabolic Diseases—Organ-Specificity and Possible Mechanisms

S Paavonsalo, S Hariharan, MH Lackman, S Karaman - Cells, 2020 - mdpi.com
Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders
are the leading causes of death and disability worldwide. Metabolic diseases cause …

Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction: cross-sectional study

G Walther, P Obert, F Dutheil, R Chapier… - … , and vascular biology, 2015 - Am Heart Assoc
Objectives—The first objective of this study was to demonstrate differences within
endothelial-dependent and endothelial-independent vasoreactivity in macro-and …

Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: the RESOLVE* randomized trial

F Dutheil, G Lac, B Lesourd, R Chapier… - International journal of …, 2013 - Elsevier
Background Opinions differ over the exercise modalities that best limit cardiovascular risk
(CVR) resulting from visceral obesity in individuals with metabolic syndrome (MetS). As little …

Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: an overview

N Toda, T Okamura - The Journal of Clinical Pharmacology, 2013 - Wiley Online Library
Obesity dramatically increases the risk of development of cardiovascular and metabolic
diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs …

Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysis

D Montero, G Walther, A Pérez-Martin, N Vicente-Salar… - Diabetologia, 2013 - Springer
Aims/hypothesis In type 2 diabetes, in contrast to the well-documented endothelial
dysfunction, studies assessing vascular smooth muscle (VSM) function have yielded …

Oxidative stress and vascular damage in the context of obesity: The hidden guest

E Martínez-Martínez, F V. Souza-Neto… - Antioxidants, 2021 - mdpi.com
The vascular system plays a central role in the transport of cells, oxygen and nutrients
between different regions of the body, depending on the needs, as well as of metabolic …

Exercise training and cardiometabolic diseases: focus on the vascular system

FR Roque, R Hernanz, M Salaices… - Current hypertension …, 2013 - Springer
The regular practice of physical activity is a well-recommended strategy for the prevention
and treatment of several cardiovascular and metabolic diseases. Physical exercise prevents …

Prevention and endothelial therapy of coronary artery disease

M Barton - Current opinion in pharmacology, 2013 - Elsevier
Functional integrity of endothelial cells is an indicator and a prerequisite for vascular health
and counteracts the development of atherosclerosis. This concept of 'endothelial …

Effect of aerobic exercise training on arterial stiffness in obese populations: a systematic review and meta-analysis

D Montero, CK Roberts, A Vinet - Sports Medicine, 2014 - Springer
Abstract Background and Objective Controversy exists as to whether aerobic exercise
training decreases arterial stiffness in obese subjects. The aim of this study was to …