Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …

The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …

Close appositions between the membrane of the endoplasmic reticulum (ER) and other
intracellular membranes have important functions in cell physiology. These include lipid …

Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER)
is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Membrane contact sites enable interorganelle communication by positioning organelles in
close proximity using molecular" tethers." With a growing understanding of the importance of …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …