Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-
fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral drugs, antipsychotic, and …

Microglial activation underpins the methotrexate (MTX)-induced neurotoxicity; however, the
precise mechanism remains unclear. This study appraised the potential impact of apigenin …

Methotrexate (MTX) is a widely used neurotoxic drug with broad antineoplastic and
immunosuppressant spectra. However, the exact molecular mechanisms by which MTX …

Methotrexate (MTX) has been used in treating various types of cancers but can also cause
damage to normal organs and cell types. Folinic acid (FA) is a well-known MTX antidote that …

Acute lymphoblastic leukemia is the most common malignancy in children. Long-term
survival exceeds 90%; however, therapy-induced toxicity remains a concern. Methotrexate …

Introducción: La literatura señala que el cáncer más frecuente en la edad infantil es la
leucemia. Su origen guarda relación con la aparición de células cancerosas como resultado …

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood
whose long-term survival has increased up to 80% thanks to modern therapy …

Background Cancer is the second most common cause of death among children aged 1–14
years in the USA. Pediatric malignancies have elevated morbidity and mortality in the …

Hematologic malignancies have a growing variety of therapeutic options, but many of these
have both central and peripheral nervous system side effects, which may force the physician …

Аннотация Высокодозный метотрексат широко используется при различных
онкогематологических заболеваниях у детей. Случаи тяжелой острой и подострой …