Discovery and validation of Lmj_04_BRCT domain, a novel therapeutic target: identification of candidate drugs for leishmaniasis
J Peña-Guerrero, C Fernández-Rubio… - International Journal of …, 2021 - mdpi.com
Since many of the currently available antileishmanial treatments exhibit toxicity, low
effectiveness, and resistance, search and validation of new therapeutic targets allowing the …
effectiveness, and resistance, search and validation of new therapeutic targets allowing the …
Nanotechnology enabled the enhancement of antitrypanosomal activity of piperine against Trypanosoma evansi
Nanoencapsulation is the promising approach to enhance the therapeutic potential of a
drug. In the present investigation, piperine-loaded nanocapsules (NCs) was prepared and …
drug. In the present investigation, piperine-loaded nanocapsules (NCs) was prepared and …
Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs
Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioactive
compounds in many plants and have stimulated a resurgence of interest in the past decades …
compounds in many plants and have stimulated a resurgence of interest in the past decades …
[HTML][HTML] Gum-based nanocapsules comprising naphthoquinones enhance the apoptotic and trypanocidal activity against Trypanosoma evansi
Nanoencapsulation is a promising approach to enhance the therapeutic potential of a drug.
Herein, three selected naphthoquinone (NTQ) derivatives, based on the IC 50 value against …
Herein, three selected naphthoquinone (NTQ) derivatives, based on the IC 50 value against …
In vitro anti-trypanosomal effect of ivermectin on Trypanosoma evansi by targeting multiple metabolic pathways
High cytotoxicity and increasing resistance reports of existing chemotherapeutic agents
against T. evansi have raised the demand for novel, potent, and high therapeutic index …
against T. evansi have raised the demand for novel, potent, and high therapeutic index …
Naphthoquinone derivatives exhibit apoptosis-like effect and anti-trypanosomal activity against Trypanosoma evansi
Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …
In vitro and in vivo evaluation of kinase and protease inhibitors against Trypanosoma evansi
Trypanosoma evansi is a causative agent of chronic wasting and fatal disease of livestock
and wild animals known as surra. In this study, repurposing approach based on drug target …
and wild animals known as surra. In this study, repurposing approach based on drug target …
Gene expression study to elucidate the anti-trypanosomal activity of quinapyramine methyl sulphate (QPS)
The kinetoplastid protozoan parasite, Trypanosoma evansi causes a fatal disease condition
known as Surra in equines throughout the globe. Disease condition being acute in nature …
known as Surra in equines throughout the globe. Disease condition being acute in nature …
Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi
Trypanosoma evansi, a hemoflagellate poses huge economic threat to the livestock industry
of several countries of Asia, Africa, South America and Europe continents of the world …
of several countries of Asia, Africa, South America and Europe continents of the world …
Study of mRNA expression levels in steady state Trypanosoma evansi for plausible selection of housekeeping and drug target genes
S Gupta, S Vohra, R Kumar - 2023 - indianjournals.com
Surra is a dreadful infectious protozoan disease affecting many animal hosts. Emerging drug
resistance, a limited number of drugs, and their high cytotoxicity have motivated researchers …
resistance, a limited number of drugs, and their high cytotoxicity have motivated researchers …