[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

X Bian, W Wu, L Yang, L Lv, Q Wang, Y Li… - Frontiers in …, 2019 - frontiersin.org
Inflammatory bowel diseases (IBDs) develop as a result of complex interactions among
genes, innate immunity and environmental factors, which are related to the gut microbiota …

Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced …

X Shao, C Sun, X Tang, X Zhang, D Han… - Journal of Agricultural …, 2020 - ACS Publications
Garlic polysaccharides are great potential agents because of their anti-inflammation,
antioxidation, and immunomodulation properties. However, few studies have reported their …

Chemically induced mouse models of acute and chronic intestinal inflammation

S Wirtz, V Popp, M Kindermann, K Gerlach… - Nature protocols, 2017 - nature.com
Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Z Wang, WH Chen, SX Li, ZM He, WL Zhu, YB Ji… - Molecular …, 2021 - nature.com
Sleep deprivation (SD) is increasingly common in modern society, which can lead to the
dysregulation of inflammatory responses and cognitive impairment, but the mechanisms …

MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis

D Yao, W Dai, M Dong, C Dai, S Wu - EBioMedicine, 2021 - thelancet.com
Abstract The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct
contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to …

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

P Praveschotinunt, AM Duraj-Thatte, I Gelfat… - Nature …, 2019 - nature.com
Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease,
fistulae and ulcers. While most treatments for such diseases focus on systemically delivered …

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis

LCH Yu - Journal of biomedical science, 2018 - Springer
Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the
interaction of genetic, environmental, barrier and microbial factors leading to chronic …