Neuroscience of apathy and anhedonia: a transdiagnostic approach

M Husain, JP Roiser - Nature Reviews Neuroscience, 2018 - nature.com
Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

Depression, anxiety, and apathy in mild cognitive impairment: current perspectives

L Ma - Frontiers in aging neuroscience, 2020 - frontiersin.org
Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly
Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed …

[HTML][HTML] Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

KL Lanctôt, J Amatniek, S Ancoli-Israel… - Alzheimer's & Dementia …, 2017 - Elsevier
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

[HTML][HTML] The anatomy of apathy: a neurocognitive framework for amotivated behaviour

C Le Heron, MAJ Apps, M Husain - Neuropsychologia, 2018 - Elsevier
Apathy is a debilitating syndrome associated with many neurological disorders, including
several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's …

Korsakoff's syndrome: a critical review

NJM Arts, SJW Walvoort… - … disease and treatment, 2017 - Taylor & Francis
In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in
patients who suffered from a Wernicke encephalopathy (WE) that is predominantly …

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

K Rascovsky, JR Hodges, D Knopman, MF Mendez… - Brain, 2011 - academic.oup.com
Based on the recent literature and collective experience, an international consortium
developed revised guidelines for the diagnosis of behavioural variant frontotemporal …

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

J Pagonabarraga, J Kulisevsky, AP Strafella… - The Lancet …, 2015 - thelancet.com
Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

Behavioral and psychological symptoms of dementia

J Cerejeira, L Lagarto… - Frontiers in neurology, 2012 - frontiersin.org
Behavioral and psychological symptoms of dementia (BPSD), also known as
neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms …

Neuropsychiatric symptoms in Alzheimer's disease

CG Lyketsos, MC Carrillo, JM Ryan… - Alzheimer's & …, 2011 - Elsevier
Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related
dementias. Once thought to emerge primarily in people with late-stage disease, these …

Diagnostic criteria for apathy in neurocognitive disorders

DS Miller, P Robert, L Ereshefsky, L Adler… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Apathy is common in neurocognitive disorders (NCD) but NCD‐specific
diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials …