Structure–Activity Relationship of Synthetic Cathinones: An Updated Review

N Nadal-Gratacós, MD Pazos, D Pubill… - ACS Pharmacology & …, 2024 - ACS Publications
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …

Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats

A Gutierrez, KM Creehan, Y Grant, MA Taffe - Psychopharmacology, 2024 - Springer
Rationale Use of electronic drug delivery systems (EDDS,“e-cigarettes”) to ingest nicotine
and Δ9-tetrahydrocannabinol (THC) has surged in adolescents in the USA; five times as …

Structure–Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP)

RA Davies, VT Nguyen, JM Eltit… - ACS Chemical …, 2023 - ACS Publications
α-Pyrrolidinohexiophenone (α-PHP) is the one-carbon unit α-extended homolog of the better-
known and widely abused synthetic cathinone central stimulant α-PVP (“flakka”); both are …

Adult consequences of repeated nicotine vapor inhalation in adolescent rats

A Gutierrez, JD Nguyen, KM Creehan… - Nicotine and …, 2024 - academic.oup.com
Introduction There has been a resurgence in nicotine inhalation in adolescents due to the
popularity and availability of Electronic Nicotine Delivery Systems (ENDS). Almost five times …

Synthetic Cathinones: Epidemiology, Toxicity, Potential for Abuse, and Current Public Health Perspective

S Chen, W Zhou, M Lai - Brain Sciences, 2024 - mdpi.com
Synthetic cathinones, derived from cathinone found in the plant Catha edulis, represent the
second largest and most frequently seized group of new psychoactive substances. They are …

Comparison of locomotor stimulant and drug discrimination effects of four synthetic cathinones to commonly abused psychostimulants

RA Shetty, AC Hoch, N Sumien… - Journal of …, 2023 - journals.sagepub.com
Background: The underground market is constantly flooded with newer synthetic as
alternatives to the older cathinones. Drug Enforcement Administration (DEA) has identified …

Fatal intoxication by the novel cathinone 4-fluoro-3-methyl-α-PVP

JM Hobbs, RT DeRienz, DD Baker… - Journal of Analytical …, 2022 - academic.oup.com
A 30 year old non-hispanic white male was found unresponsive at his workplace and
admitted to the hospital in cardiac arrest. He was pronounced deceased shortly after arrival …

A new synthetic cathinone: 3, 4‐EtPV or 3, 4‐Pr‐PipVP? An unsuccessful attempt to circumvent the German legislation on new psychoactive substances

B Pulver, J Riedel, F Westphal, S Luhn… - Drug Testing and …, 2023 - Wiley Online Library
Synthetic cathinones comprise psychostimulants with desired effects like euphoria,
increased vigilance, appetite suppression, and—mainly depending on certain structural …

Alpha pyrrolidinovalerophenone (α-PVP) administration impairs spatial learning and memory in rats through brain mitochondrial dysfunction

M Noruzi, H Behmadi, ZH Khankahdani… - Toxicology and Applied …, 2023 - Elsevier
Novel psychoactive substances (NPS) consumption has increased in recent years, thus NPS-
induced cognitive decline is a current source of concern. Alpha-pyrrolidinovalerophenone (α …

α-Pyrrolidinohexanophenone (α-PHP) vs. α-pyrrolidinoisohexanophenone (α-PiHP): A toxicological investigation about plasma concentrations and behavior in …

I Brueckner, J Welter-Luedeke, A Zangl… - Journal of Analytical …, 2024 - academic.oup.com
New psychoactive substances (NPS), like pyrrolidinophenones, are still very present on the
illegal drug market. The presented study reports on two members of this substance group, α …