[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …
interacting systems. In AD, skin inflammation is caused by host–environment interactions …
Targeting the Janus kinase family in autoimmune skin diseases
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
[HTML][HTML] Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by …
Background Interleukin 22 promotes epidermal hyperplasia and inhibits skin barrier
function. Objective Evaluate interleukin 22 blockade in adults with moderate-to-severe …
function. Objective Evaluate interleukin 22 blockade in adults with moderate-to-severe …
Keratinocytes: innate immune cells in atopic dermatitis
P Chieosilapatham, C Kiatsurayanon… - Clinical & …, 2021 - academic.oup.com
The skin is a unique immune organ that constitutes a complex network of physical, chemical
and microbiological barriers against external insults. Keratinocytes are the most abundant …
and microbiological barriers against external insults. Keratinocytes are the most abundant …
Itch: Pathogenesis and treatment
Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …
Selective JAK1 inhibitors for the treatment of atopic dermatitis: focus on upadacitinib and abrocitinib
S Ferreira, E Guttman-Yassky, T Torres - American journal of clinical …, 2020 - Springer
Atopic dermatitis is a common, chronic, immune-mediated disease associated with several
comorbidities. Elevated levels of T helper (Th) 2, Th22, and also some Th1 and Th17 …
comorbidities. Elevated levels of T helper (Th) 2, Th22, and also some Th1 and Th17 …
Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches
Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is
characterized by persistent itch and marked redness. AD is associated with an increased …
characterized by persistent itch and marked redness. AD is associated with an increased …
Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options
T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …
with a high skin‐related health burden, typically starting in childhood and often persisting …
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab
Background IL-22 is potentially a pathogenic cytokine in patients with atopic dermatitis (AD),
but the molecular effects of IL-22 antagonism have not been defined in human subjects …
but the molecular effects of IL-22 antagonism have not been defined in human subjects …
Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization
M Belzberg, MP Alphonse, I Brown, KA Williams… - Journal of Investigative …, 2021 - Elsevier
Prurigo nodularis (PN) is an understudied, chronic inflammatory skin disease that
disproportionately affects African Americans and presents with intensely pruritic nodules of …
disproportionately affects African Americans and presents with intensely pruritic nodules of …