This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

The wide distribution of ATP and adenosine receptors as well as enzymes for purine
metabolism in different gut regions suggests a complex role for these mediators in the …

The kynurenine metabolites of tryptophan may be involved in the regulation of neuronal
activity and thus gut motility and secretion. We have now performed a pilot study to measure …

1 Functional interactions between nicotinic and P2X receptors in submucosal neurons were
investigated. Whole‐cell currents induced by ACh (IACh) and ATP (IATP) were blocked by …

Melatonin, a hormone produced and released by the pineal gland, is also synthesized by
cells of the gastrointestinal wall, where it might be a local regulator of gut functions. In this …

Most of the physiological information on the enteric nervous system has been obtained from
studies on preparations of the myenteric ganglia attached to the longitudinal muscle layer …

Synaptic transmission between neurones intrinsic to the wall of the intestine involves
multiple neurotransmitters. This study aimed to identify neurotransmitters responsible for non …

Adenine and uracil nucleotides play key functions in the autonomic nervous system (ANS).
For instance, ATP acts as a neurotransmitter, co-transmitter and neuromodulator in the ANS …