The osteocyte: an endocrine cell… and more
Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …
Osteocytes: master orchestrators of bone
MB Schaffler, WY Cheung, R Majeska… - Calcified tissue …, 2014 - Springer
Osteocytes comprise the overwhelming majority of cells in bone and are its only true
“permanent” resident cell population. In recent years, conceptual and technological …
“permanent” resident cell population. In recent years, conceptual and technological …
Osteoporosis: mechanism, molecular target and current status on drug development
Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling
where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation …
where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation …
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Sclerostin, the Wnt signaling antagonist encoded by the Sost gene, is secreted by
osteocytes and inhibits bone formation by osteoblasts. Mechanical stimulation reduces …
osteocytes and inhibits bone formation by osteoblasts. Mechanical stimulation reduces …
Osteocyte mechanobiology
Abstract Purpose of Review Over the past decades, osteocytes have emerged as mechano-
sensors of bone and master regulators of bone homeostasis. This article summarizes latest …
sensors of bone and master regulators of bone homeostasis. This article summarizes latest …
Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone
X Xu, S Liu, H Liu, K Ru, Y Jia, Z Wu, S Liang… - International Journal of …, 2021 - mdpi.com
Piezo channels are mechanosensitive ion channels located in the cell membrane and
function as key cellular mechanotransducers for converting mechanical stimuli into …
function as key cellular mechanotransducers for converting mechanical stimuli into …
Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation
N Bivi, KW Condon, MR Allen, N Farlow… - Journal of Bone and …, 2012 - academic.oup.com
Abstract Connexin 43 (Cx43) mediates osteocyte communication with other cells and with
the extracellular milieu and regulates osteoblastic cell signaling and gene expression. We …
the extracellular milieu and regulates osteoblastic cell signaling and gene expression. We …
Muscle-bone interactions: From experimental models to the clinic? A critical update
MR Laurent, V Dubois, F Claessens… - Molecular and cellular …, 2016 - Elsevier
Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …
Bone and skeletal muscle: key players in mechanotransduction and potential overlapping mechanisms
CA Goodman, TA Hornberger, AG Robling - Bone, 2015 - Elsevier
The development and maintenance of skeletal muscle and bone mass is critical for
movement, health and issues associated with the quality of life. Skeletal muscle and bone …
movement, health and issues associated with the quality of life. Skeletal muscle and bone …
Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies
In recent years, technical developments in mouse genetics and imaging equipment have
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …