Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

Circular RNAs with exonic sequences represent a special form of non-coding RNAs,
discovered by analyzing a handful of transcribed genes. It has been observed that circular …

Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …

The Rho family of small guanosine triphosphatases regulates actin cytoskeleton dynamics
that underlie cellular functions such as cell shape changes, migration, and polarity. We …

Ubiquitination of the chemokine receptor CXCR4 serves as a targeting signal for lysosomal
degradation, but the mechanisms mediating ubiquitination and lysosomal sorting remain …

Domains have been identified in the Gag proteins of a number of retroviruses, and in the
matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

The conjugation of ubiquitin to proteins involves a cascade of activating (E1), conjugating
(E2), and ubiquitin-ligating (E3) type enzymes that commonly signal protein destruction. In …

p73, a member of the p53 family of transcription factors, is upregulated in response to DNA
damage, inducing cell cycle arrest and apoptosis. Besides indications that this p73 response …