Sex and gender issues in multiple sclerosis

HF Harbo, R Gold, M Tintoré - Therapeutic advances in …, 2013 - journals.sagepub.com
Multiple sclerosis (MS) is universally found to be more prevalent in women than men. This
has led to extensive studies of differences in the immune system or nervous system between …

Inflammatory bowel disease in pregnancy and breastfeeding

MN Brondfield, U Mahadevan - Nature Reviews Gastroenterology & …, 2023 - nature.com
Inflammatory bowel disease (IBD) has a peak age of diagnosis before the age of 35 years.
Concerns about infertility, adverse pregnancy outcomes, and heritability of IBD have …

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

X Montalban, R Gold, AJ Thompson… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Exclusive breastfeeding and the effect on postpartum multiple sclerosis relapses

K Hellwig, M Rockhoff, S Herbstritt, N Borisow… - JAMA …, 2015 - jamanetwork.com
Importance Women with multiple sclerosis (MS) experience an elevated risk of relapse after
giving birth. The effect of exclusive breastfeeding on postpartum risk of MS relapse is …

Natalizumab use during the third trimester of pregnancy

A Haghikia, A Langer-Gould, G Rellensmann… - JAMA …, 2014 - jamanetwork.com
Importance Natalizumab reduces multiple sclerosis relapses very effectively; however,
severe disease activity may return once natalizumab treatment is withdrawn, as …

Evaluation of pregnancy outcomes from the Tysabri®(natalizumab) pregnancy exposure registry: a global, observational, follow-up study

S Friend, S Richman, G Bloomgren, LM Cristiano… - BMC neurology, 2016 - Springer
Background Patients with multiple sclerosis (MS) or Crohn's disease (CD) being treated with
natalizumab (Tysabri®, Biogen) who are planning to become pregnant or discover they are …

Disease-modifying drugs for multiple sclerosis in pregnancy: a systematic review

E Lu, BW Wang, C Guimond, A Synnes, D Sadovnick… - Neurology, 2012 - AAN Enterprises
Objective: To systematically review the literature regarding safety of disease-modifying drug
(DMD) use during pregnancy on perinatal and developmental outcomes in offspring of …

Monoclonal antibody treatment during pregnancy and/or lactation in women with MS or neuromyelitis optica spectrum disorder

AI Ciplea, A Langer-Gould, A de Vries… - Neurology …, 2020 - AAN Enterprises
Objective To assess possible adverse effects on breastfed infants of mothers receiving
monoclonal antibodies (MAbs) during pregnancy and/or lactation. Methods We identified 23 …

Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis

G Karlsson, G Francis, G Koren, P Heining, X Zhang… - Neurology, 2014 - AAN Enterprises
Objective: To report outcomes of pregnancies that occurred during the fingolimod clinical
development program. Methods: Pregnancy outcomes from phase II, phase III, and phase IV …

Recurrence or rebound of clinical relapses after discontinuation of natalizumab therapy in highly active MS patients

PS Sorensen, N Koch-Henriksen, T Petersen… - Journal of …, 2014 - Springer
A number of studies have reported flare-up of multiple sclerosis (MS) disease activity after
cessation of natalizumab, increasing to a level beyond the pre-natalizumab treatment level …