Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside?
One year after the occurrence of the first case of infection by the Middle East Respiratory
Syndrome coronavirus (MERS-CoV) there is no clear consensus on the best treatment to …
Syndrome coronavirus (MERS-CoV) there is no clear consensus on the best treatment to …
[HTML][HTML] IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease
The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by
many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ …
many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ …
Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells
Z Zhao, M Condomines, SJC van der Stegen, F Perna… - Cancer cell, 2015 - cell.com
T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The
costimulatory properties of second-generation chimeric antigen receptors (CARs) determine …
costimulatory properties of second-generation chimeric antigen receptors (CARs) determine …
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA: DNA synthesis
Aberrant nucleic acids generated during viral replication are the main trigger for antiviral
immunity, and mutations that disrupt nucleic acid metabolism can lead to autoinflammatory …
immunity, and mutations that disrupt nucleic acid metabolism can lead to autoinflammatory …
Tc17 biology and function: Novel concepts
C Lückel, FSR Picard, M Huber - European Journal of …, 2020 - Wiley Online Library
Research over the past years has provided increasing understanding about IL‐17‐
producing CD8+ T cells termed Tc17 or IL‐17+ CD8+ T cells, their distribution and role in a …
producing CD8+ T cells termed Tc17 or IL‐17+ CD8+ T cells, their distribution and role in a …
COVID‐19 immunopathology with emphasis on Th17 response and cell‐based immunomodulation therapy: potential targets and challenges
A Pourgholaminejad… - Scandinavian Journal …, 2022 - Wiley Online Library
The role of the immune system against coronavirus disease 2019 (COVID‐19) is unknown in
many aspects, and the protective or pathologic mechanisms of the immune response are …
many aspects, and the protective or pathologic mechanisms of the immune response are …
Opposing roles of IL-10 in acute bacterial infection
HF Peñaloza, BM Schultz, PA Nieto, GA Salazar… - Cytokine & growth factor …, 2016 - Elsevier
Abstract Interleukin-10 (IL-10) is recognized as an anti-inflammatory cytokine that
downmodulates inflammatory immune responses at multiple levels. In innate cells …
downmodulates inflammatory immune responses at multiple levels. In innate cells …
IFN regulatory factor 3 in health and disease
TM Petro - The Journal of Immunology, 2020 - journals.aai.org
Immunity to viruses requires an array of critical cellular proteins that include IFN regulatory
factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that …
factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that …
TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
Interleukin (IL)-17–producing CD8+ T (Tc17) cells have emerged as key players in host-
microbiota interactions, infection, and cancer. The factors that drive their development, in …
microbiota interactions, infection, and cancer. The factors that drive their development, in …
Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3
P Tang, S Virtue, JYG Goie, CW Png, J Guo… - Cell Death & …, 2021 - nature.com
Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-
associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in …
associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in …