Combating implant infections: shifting focus from bacteria to host

S Amin Yavari, SM Castenmiller… - Advanced …, 2020 - Wiley Online Library
The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

Infection after fracture fixation: current surgical and microbiological concepts

WJ Metsemakers, R Kuehl, TF Moriarty, RG Richards… - Injury, 2018 - Elsevier
One of the most challenging complications in trauma surgery is infection after fracture
fixation (IAFF). IAFF may result in permanent functional loss or even amputation of the …

[HTML][HTML] Biofilms: Formation, drug resistance and alternatives to conventional approaches

R Mirghani, T Saba, H Khaliq, J Mitchell, L Do… - AIMS …, 2022 - ncbi.nlm.nih.gov
Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-
spectrum antibiotics in their typical concentrations or even in higher doses. A trend of …

Options and limitations in clinical investigation of bacterial biofilms

M Magana, C Sereti, A Ioannidis… - Clinical Microbiology …, 2018 - Am Soc Microbiol
Bacteria can form single-and multispecies biofilms exhibiting diverse features based upon
the microbial composition of their community and microenvironment. The study of bacterial …

Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection

M Sabaté Brescó, LG Harris, K Thompson… - Frontiers in …, 2017 - frontiersin.org
Staphylococcus epidermidis is a permanent member of the normal human microbiota,
commonly found on skin and mucous membranes. By adhering to tissue surface moieties of …

Chronic implant-related bone infections—can immune modulation be a therapeutic strategy?

E Seebach, KF Kubatzky - Frontiers in immunology, 2019 - frontiersin.org
Chronic implant-related bone infections are a major problem in orthopedic and trauma-
related surgery with severe consequences for the affected patients. As antibiotic resistance …

Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects

CT Johnson, MCP Sok, KE Martin, PP Kalelkar… - Science …, 2019 - science.org
Staphylococcus aureus is the most common pathogen associated with bacterial infections in
orthopedic procedures. Infections often lead to implant failure and subsequent removal …

Impact of bacterial infections on osteogenesis: evidence from in vivo studies

M Croes, BCH van der Wal… - Journal of Orthopaedic …, 2019 - Wiley Online Library
The clinical impact of bacterial infections on bone regeneration has been incompletely
quantified and documented. As a result, controversy exists about the optimal treatment …

Interactions between the foreign body reaction and Staphylococcus aureus biomaterial-associated infection. Winning strategies in the derby on biomaterial implant …

CWK Rosman, JM van Dijl… - Critical Reviews in …, 2022 - Taylor & Francis
Biomaterial-associated infections (BAIs) are an increasing problem where antibiotic
therapies are often ineffective. The design of novel strategies to prevent or combat infection …

Innovations in osteomyelitis research: A review of animal models

KM Roux, LH Cobb, MA Seitz… - Animal models and …, 2021 - Wiley Online Library
Infection of bone tissue, or osteomyelitis, has become a growing concern in modern
healthcare due in no small part to a rise in antibiotic resistance among bacteria, notably …