Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Potassium inward rectifier channel Kir2 is an important component of terminal cardiac
repolarization and resting membrane stability. This functionality is part of balanced cardiac …

Andersen-Tawil syndrome (ATS) is a rare inheritable disease associated with loss-of-
function mutations in KCNJ2, the gene coding the strong inward rectifier potassium channel …

BACKGROUND: Viral cardiac infection represents a significant clinical challenge
encompassing several etiological agents, disease stages, complex presentation, and a …

All-trans retinoic acid and arsenic trioxide are the leading choices for the treatment of acute
promyelocytic leukemia. Notwithstanding the impressive differentiative properties of all-trans …

Membrane proteins represent a large family of proteins that perform vital physiological roles
and represent key drug targets. Despite their importance, bioanalytical methods aiming to …

Several ion currents in the mammalian ventricular myocardium are substantially regulated
by the sympathetic nervous system via β-adrenergic receptor activation, including the slow …

In modern cardiovascular research, isolated perfused hearts have become cost-effective
and highly reproducible tools to investigate the mechanisms of cardiovascular diseases …

Alteration of the inward rectifier current IK 1, carried by KIR2. 1 channels, affects action
potential duration, impacts resting membrane stability and associates with cardiac …

Cardiovascular diseases (CVDs) are the leading causes of death globally that seriously
threaten human health. Although novel western medicines have continued to be discovered …