The structure and function of biomolecules are strongly influenced by their hydration shells.
Structural fluctuations and molecular excitations of hydrating water molecules cover a broad …

Water is an essential participant in the stability, structure, dynamics, and function of proteins
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …

When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

This review describes selected basics of water in biomolecular recognition. We focus on a
qualitative understanding of the most important physical aspects, how these change in …

The extent of the effect of cellular crowding and cosolutes on the functioning of proteins and
cells is manifold and includes the stabilization of the biomolecular systems, the excluded …

Water–biomolecule interactions have been extensively studied in dilute solutions, crystals,
and rehydrated powders, but none of these model systems may capture the behavior of …

Even after a century of investigation, our understanding of how enzymes work remains far
from complete. In particular, several factors that enable enzymes to achieve high catalytic …

We present a molecular dynamics simulation study of the structure and dynamics of water
confined between silica surfaces using β-cristobalite as a model template. We scale the …

When Szent-Györgyi1 called water the “matrix of life,” he was echoing an old sentiment.
Paracelsus, in the sixteenth century, said that “water was the matrix of the world and of all its …

In this work, we combine atomistic molecular dynamics simulations with theoretical
vibrational spectroscopy to study the properties of water confined inside bis (2-ethylhexyl) …