Chemotherapeutic drugs and mitochondrial dysfunction: focus on doxorubicin, trastuzumab, and sunitinib

S Gorini, A De Angelis, L Berrino… - Oxidative medicine …, 2018 - Wiley Online Library
Many cancer therapies produce toxic side effects whose molecular mechanisms await full
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …

Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management …

SE Lipshultz, MJ Adams, SD Colan, LS Constine… - Circulation, 2013 - Am Heart Assoc
1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron

T Šimůnek, M Štěrba, O Popelová, M Adamcová… - Pharmacological …, 2009 - Elsevier
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of
anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin) …

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection

M Štěrba, O Popelová, A Vávrová… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Significance: Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among
the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of …

Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity

F Aminkeng, CJD Ross, SR Rassekh… - British journal of …, 2016 - Wiley Online Library
Aims Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and
remains an important limitation of anthracycline‐based chemotherapy. In various genetic …

Anthracycline cardiotoxicity: from bench to bedside

L Gianni, EH Herman, SE Lipshultz, G Minotti… - Journal of Clinical …, 2008 - ascopubs.org
Anthracyclines remain among the most widely prescribed and effective anticancer agents.
Unfortunately, life-threatening cardiotoxicity continues to compromise their usefulness …

Predicting and preventing anthracycline-related cardiotoxicity

S Armenian, S Bhatia - … Society of Clinical Oncology Educational Book, 2018 - ascopubs.org
Anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin) are among the most
potent chemotherapeutic agents and have truly revolutionized the management of childhood …

Cardiovascular effects of systemic cancer treatment

E Senkus, J Jassem - Cancer treatment reviews, 2011 - Elsevier
Many methods of systemic anticancer treatment have detrimental effects on the
cardiovascular system, thus limiting the possibility of further therapy, worsening patients' …

Exploring the use of cold atmospheric plasma to overcome drug resistance in cancer

D Murillo, C Huergo, B Gallego, R Rodríguez, J Tornín - Biomedicines, 2023 - mdpi.com
Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of
pharmacological agents and can lead to disease progression. Cold atmospheric plasma …

Evidence-based risk assessment and recommendations for physical activity clearance: Consensus Document 2011

DER Warburton, N Gledhill, VK Jamnik… - Applied Physiology …, 2011 - cdnsciencepub.com
The Physical Activity Readiness Questionnaire (PAR-Q) and the Physical Activity Readiness
Medical Evaluation (PARmed-X) are internationally known preparticipation screening tools …