Biomaterials to mimic and heal connective tissues
BR Freedman, DJ Mooney - Advanced Materials, 2019 - Wiley Online Library
Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
[HTML][HTML] Regulators of collagen crosslinking in developing and adult tendons
AJ Ellingson, NM Pancheri… - European cells & …, 2022 - ncbi.nlm.nih.gov
Tendons are collagen-rich musculoskeletal tissues that possess the mechanical strength
needed to transfer forces between muscles and bones. The mechanical development and …
needed to transfer forces between muscles and bones. The mechanical development and …
Flaw-insensitive fatigue resistance of chemically fixed collagenous soft tissues
Bovine pericardium (BP) has been used as leaflets of prosthetic heart valves. The leaflets
are sutured on metallic stents and can survive 400 million flaps (~ 10-year life span) …
are sutured on metallic stents and can survive 400 million flaps (~ 10-year life span) …
Circadian control of the secretory pathway maintains collagen homeostasis
Collagen is the most abundant secreted protein in vertebrates and persists throughout life
without renewal. The permanency of collagen networks contrasts with both the continued …
without renewal. The permanency of collagen networks contrasts with both the continued …
[HTML][HTML] Tendon tissue microdamage and the limits of intrinsic repair
T Stauber, U Blache, JG Snedeker - Matrix Biology, 2020 - Elsevier
The transmission of mechanical muscle force to bone for musculoskeletal stability and
movement is one of the most important functions of tendon. The load-bearing tendon core is …
movement is one of the most important functions of tendon. The load-bearing tendon core is …
Tendon explant models for physiologically relevant in vitro study of tissue biology – a perspective
SL Wunderli, U Blache, JG Snedeker - Connective tissue research, 2020 - Taylor & Francis
Background: Tendon disorders increasingly afflict our aging society but we lack the scientific
understanding to clinically address them. Clinically relevant models of tendon disease are …
understanding to clinically address them. Clinically relevant models of tendon disease are …
Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading
Tendon pathology is associated with damage. While tendon damage is likely initiated by
mechanical loading, little is known about the specific etiology. Damage is defined as an …
mechanical loading, little is known about the specific etiology. Damage is defined as an …
[HTML][HTML] Innate and adaptive immune cells implicated in tendon healing and disease
G Crosio, AH Huang - European cells & materials, 2022 - ncbi.nlm.nih.gov
Tendons perform a critical function in the musculoskeletal system by integrating muscle with
skeleton and enabling force transmission. Damage or degeneration of these tissues leads to …
skeleton and enabling force transmission. Damage or degeneration of these tissues leads to …
Structural determinants of tendon multiscale mechanics and their sensitivity to mechanical stimulation during development in an embryonic chick model
There is an abrupt increase in the multiscale mechanical properties and load-bearing
capabilities of tendon during development. While prior work has identified numerous …
capabilities of tendon during development. While prior work has identified numerous …
Collagen fibrils from both positional and energy-storing tendons exhibit increased amounts of denatured collagen when stretched beyond the yield point
Collagen molecules are the base structural unit of tendons, which become denatured during
mechanical overload. We recently demonstrated that during tendon stretch, collagen …
mechanical overload. We recently demonstrated that during tendon stretch, collagen …