Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic
histopathological changes ranging from non-inflammatory intracellular fat deposition to non …

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms
are poorly understood. Using cell culture and mouse models, we show that obesity causes …

Over the past few decades, understandings and evidences concerning the role of
endoplasmic reticulum (ER) stress in deciding the cell fate have been constantly growing …

The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins
through various chaperones and enzymes residing within the ER organelle. Perturbation in …

Lengthening a glutamine tract in huntingtin confers a dominant attribute that initiates
degeneration of striatal neurons in Huntington's disease (HD). To identify pathways that are …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …

Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases
are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals …

Endoplasmic reticulum (ER) stress is a general term for representing the pathway by which
various stimuli affect ER functions. ER stress induces the evolutionarily conserved signaling …

Preclinical and clinical findings suggest that tumor-specific immune responses may be
responsible–at least in part–for the clinical success of therapeutic regimens that rely on …