Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Delivery of genetic information to the interior of target cells in vivo has been a major
challenge facing gene therapies. This barrier is now being overcome, owing in part to …

Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever,
muscle pain, and even death in humans or ruminants. However, there are no approved …

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor
antigens into the body to activate specific anti-tumor immune responses. Along with the …

Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …

Lipid nanoparticle (LNP)–mRNA complexes are transforming medicine. However, the
medical applications of LNPs are limited by their low endosomal disruption rates, high …

The remarkable success of two FDA-approved mRNA-encapsulating vaccines (Comirnaty®
and Spikevax®) indicated the importance of lipid nanoparticles (LNPs) delivery systems in …

Immune modulation through the intracellular delivery of nucleoside-modified mRNA to
immune cells is an attractive approach for in vivo immunoengineering, with applications in …

The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies
implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the …

The delivery of mRNA molecules to organs beyond the liver is valuable for therapeutic
applications. Functionalized lipid nanoparticles (LNPs) using exogenous mechanisms can …