Insights into DNA cleavage by MutL homologs from analysis of conserved motifs in eukaryotic Mlh1
CD Putnam, RD Kolodner - BioEssays, 2023 - Wiley Online Library
MutL family proteins contain an N‐terminal ATPase domain (NTD), an unstructured
interdomain linker, and a C‐terminal domain (CTD), which mediates constitutive …
interdomain linker, and a C‐terminal domain (CTD), which mediates constitutive …
The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
SJ Witte, IM Rosa, BW Collingwood… - Nucleic Acids …, 2023 - academic.oup.com
In eukaryotic mismatch repair, MutS homologs recognize mismatches and recruit the MutLα
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …
Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence
A Mazumder, JT DeWitt, E Oropeza, N Punturi… - bioRxiv, 2024 - biorxiv.org
Estrogen receptor positive (ER+) breast cancer is one of the most common causes of cancer-
related death in women. Mortality is largely driven by recurrence of treatment-resistant …
related death in women. Mortality is largely driven by recurrence of treatment-resistant …
A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation
K Wolf, J Kosinski, TJ Gibson, N Wesch… - Nucleic Acids …, 2023 - academic.oup.com
DNA mismatch repair (MMR) is essential for correction of DNA replication errors. Germline
mutations of the human MMR gene MLH1 are the major cause of Lynch syndrome, a …
mutations of the human MMR gene MLH1 are the major cause of Lynch syndrome, a …
Mismatch Matchmaking: Single Molecule Insights into DNA Mismatch Repair Signaling
WH Wilkins - 2022 - search.proquest.com
Abstract DNA Mismatch Repair (MMR) is a universally conserved system that recognizes
errors made during the replication process, such as base-base mismatches and insertions …
errors made during the replication process, such as base-base mismatches and insertions …
Order out of disorder: Regulation of endonuclease activity during eukaryotic mismatch repair.
C Cupples - BioEssays, 2023 - search.ebscohost.com
Keywords: DNA mismatch repair; endonuclease; intrinsically disordered region; MutL
homologs EN DNA mismatch repair endonuclease intrinsically disordered region MutL …
homologs EN DNA mismatch repair endonuclease intrinsically disordered region MutL …
[图书][B] Investigating How the Endonuclease MUTLα Is Activated and Signals in DNA Mismatch Repair
S Witte - 2023 - search.proquest.com
In many DNA processes, action at a distance is required for signaling across long distances
on DNA. These pathways, generally have an initiation site (site 1) that signals an event at a …
on DNA. These pathways, generally have an initiation site (site 1) that signals an event at a …
MutS and DNA Function as a Clamp Loader for the MutL Sliding Clamp During Mismatch Repair
ABSTRACT DNA mismatch repair (MMR) is accomplished by highly conserved MutS and
MutL homologs. MutS proteins recognize mismatch nucleotides and in the presence of ATP …
MutL homologs. MutS proteins recognize mismatch nucleotides and in the presence of ATP …