Cardiotoxicity, or the development of unwarranted cardiovascular side-effects of oncologic
therapies, can involve all aspects of cardiovascular disease. The development of cardiac …

PURPOSE Interindividual variability in the dose-dependent association between
anthracyclines and cardiomyopathy suggests a modifying role of genetic susceptibility. Few …

Objective To evaluate the role of matrix metalloproteinases (MMP)-2 and 9 and the gene
polymorphisms of MMP-2 (rs243865) and MMP-9 (rs3918242) in the course of anthracycline …

Doxorubicin (DOX), a commonly used anticancer agent, causes cardiotoxicity that begins
with the first dose and may progress to heart failure years after treatment. An inflammatory …

Цель. В ходе 12-месячного исследования изучить прогностическую роль гуморальных
маркеров, ответственных за основные механизмы инициирования кардиотоксического …

Aim. To carry out a 12-month study on the prognostic role of humoral markers responsible
for the main mechanisms of initiation of cardiotoxic myocardial damage (endothelin-1 …

Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A
serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to …

Anthracyclines remain one of the most widely used classes of cancer chemotherapy with
proven efficacy across a wide range of malignancies. Despite clear anti-tumour efficacy in …

Structura tezei: manuscrisul este expus pe 127 pagini și constă din introducere, 3 capitole,
sinteza rezultatelor obținute, concluzii generale, recomandări practice, bibliografie din 174 …

Признание того, что изолированная диастолическая дисфункция (ДД) левого
желудочка (ЛЖ) лежит в основе примерно 50% всех случаев сердечной …