The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily
challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that …

With the development trend of an aging society, Alzheimer's disease (AD) has become an
urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients …

This work aimed to investigate potential pathways linking age and imaging measures to
early age-and pathology-related changes in cognition. We used [18F]-Flutemetamol …

Clinically normal females exhibit higher 18F-flortaucipir (FTP)-PET signal than males across
the cortex. However, these sex differences may be explained by neuroimaging …

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …

Passive immunotherapy for Alzheimer disease has been tried for over 10 years without
success. However, in 2021 and most recently in January 2023, the US Food and Drug …

Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We
studied how the position on this function, reflected by different Aβ accumulation phases …

Alzheimer disease (AD) is a common neurodegenerative disease with pathological features
of accumulated amyloid plaques, neurofibrillary tangles, and the significant inflammatory …

INTRODUCTION Female sex is associated with increased [18F]‐flortaucipir signal, which
may be affected by amyloid pathology, age, and off‐target binding in skull and meninges …

Aim To investigate the relationship between off-target binding of the amyloid tracer [18 F]
florbetaben (FBB) in the skull and skull density. Methods Forty-three consecutive patients …