Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the
war against cancer. However, cancers do not give up without a fight. They may develop …

It has been nearly 9years since the FDA (Food and Drug Administration) approved the first
anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other …

CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …

Abstract Background and Objective: Epigenetic alterations are common events in clear cell
renal cell carcinoma (ccRCC), and protein arginine methyltransferase 1 (PRMT1) is an …

Cancer remains one of the major cause of death in the Western world. Although, it has been
demonstrated that new therapies can improve the outcome of cancer patients, still many …

The introduction of agents that inhibit tumor angiogenesis by targeting vascular endothelial
growth factor (VEGF) signaling has made a significant impact on the survival of patients with …

Simple Summary The treatment of renal cancer is currently based on the use of
antiangiogenic drugs targeting the VEGF-A pathway and/or immunotherapy targeting …

Background A strong rationale supports the role of antiangiogenic drugs in urothelial cancer.
This trial was designed to assess the activity of sunitinib as first-line treatment in patients …