The recommendations listed in this clinical practice guideline are, whenever possible,
evidence-based. An initial extensive evidence review, which included literature derived from …

Brugada syndrome (BrS) is an “inherited” condition characterized by predisposition to
syncope and cardiac arrest, predominantly during sleep. The prevalence is∼ 1: 2,000, and …

Background: Long QT syndrome (LQTS) is the first described and most common inherited
arrhythmia. Over the last 25 years, multiple genes have been reported to cause this …

Since the early days, 2 diagnosis of the long-QT syndrome (LQTS) has undergone several
levels of progressive upgrade. Initially, the diagnosis was made only in the presence of …

Aims Genetic testing is recommended in specific inherited heart diseases but its role
remains unclear and it is not currently recommended in unexplained cardiac arrest (UCA) …

Abstract The Wnt‐Frizzled (Fzd) G‐protein‐coupled receptor system, involving 19 distinct
Wnt ligands and 10 Fzd receptors, plays key roles in the development and functioning of …

Objectives: The aim of this study was to provide the spectrum and prevalence of mutations in
the 12 Brugada syndrome (BrS)–susceptibility genes discovered to date in a single large …

Brugada syndrome is a heritable channelopathy characterized by a peculiar
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …

Aims Despite our increased understanding of the genetic basis of dilated cardiomyopathy
(DCM), the clinical utility and yield of clinically meaningful findings of comprehensive next …

Many questions remain concerning whether, when, and how physicians order genetic tests,
and what factors are involved in their decisions. We surveyed 220 internists from two …