Patients with CKD have a 4–fivefold higher rate of fractures. The incidence of fractures
increases with deterioration of kidney function. The process of skeletal changes in CKD …

Abnormal bone metabolism is an integral part of the chronic kidney disease-mineral bone
disorder (CKD-MBD). For several reasons, the difficult bone compartment was neglected for …

Purpose Trabecular bone score (TBS) is a grey-level textural measurement acquired from
dual-energy X-ray absorptiometry lumbar spine images and is a validated index of bone …

Context The impairment of bone microarchitecture is a key determinant of skeletal fragility in
patients with chronic kidney disease (CKD). The trabecular bone score (TBS) has been …

Impact microindentation (IMI) is a novel technique for assessing bone material strength
index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical …

Background: There is ample evidence that patients with CKD have an increased risk of
osteoporotic fractures. Bone fragility is not only influenced by low bone volume and mass but …

Bone Biopsy (BB) with histomorphometric analysis still represents the gold standard for the
diagnosis and classification of different forms of renal osteodystrophy. Bone biopsy is the …

The coexistence of osteoporosis and chronic kidney disease (CKD) is an evolving
healthcare challenge in the face of increasingly aging populations. Globally, accelerating …

Daily physiological activities subject our skeletal system to cyclic loading with varying
frequencies and magnitudes. These loadings interact with the microstructure of bone and …

Abstract Purpose of Review Both diabetes and kidney disease associate with the
development of bone disease and an increased risk of fragility fractures. The etiologies of …