Diversity of folds in animal toxins acting on ion channels

S Mouhat, B Jouirou, A Mosbah, M De Waard… - Biochemical …, 2004 - portlandpress.com
Animal toxins acting on ion channels of excitable cells are principally highly potent short
peptides that are present in limited amounts in the venoms of various unrelated species …

Entomo-venomics: The evolution, biology and biochemistry of insect venoms

AA Walker, SD Robinson, DK Yeates, J Jin… - Toxicon, 2018 - Elsevier
The insects are a hyperdiverse class containing more species than all other animal groups
combined—and many employ venom to capture prey, deter predators and micro-organisms …

Venoms of heteropteran insects: a treasure trove of diverse pharmacological toolkits

AA Walker, C Weirauch, BG Fry, GF King - Toxins, 2016 - mdpi.com
The piercing-sucking mouthparts of the true bugs (Insecta: Hemiptera: Heteroptera) have
allowed diversification from a plant-feeding ancestor into a wide range of trophic strategies …

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton‐gated cation channels

P Escoubas, C Bernard, G Lambeau… - Protein …, 2003 - Wiley Online Library
Acid‐sensing ion channels (ASICs) are thought to be important ion channels, particularly for
the perception of pain. Some of them may also contribute to synaptic plasticity, learning, and …

Arthropod venoms: Biochemistry, ecology and evolution

RRS Laxme, V Suranse, K Sunagar - Toxicon, 2019 - Elsevier
Comprising of over a million described species of highly diverse invertebrates, Arthropoda is
amongst the most successful animal lineages to have colonized aerial, terrestrial, and …

Solution Structure of Alo-3: A New Knottin-Type Antifungal Peptide from the Insect Acrocinus longimanus

F Barbault, C Landon, M Guenneugues, JP Meyer… - Biochemistry, 2003 - ACS Publications
Insect peptides are key elements of the innate immunity against bacteria and fungi. These
molecules offer remarkable properties: high efficacy, a low probability of resistance, limited …

An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis

B Chagot, C Pimentel, L Dai, J Pil, J Tytgat… - Biochemical …, 2005 - portlandpress.com
The Om-toxins are short peptides (23–27 amino acids) purified from the venom of the
scorpion Opisthacanthus madagascariensis. Their pharmacological targets are thought to …

Context‐dependent venom deployment and protein composition in two assassin bugs

ML Fischer, N Wielsch, DG Heckel… - Ecology and …, 2020 - Wiley Online Library
The Heteroptera are a diverse suborder of phytophagous, hematophagous, and
zoophagous insects. The shift to zoophagy can be traced back to the transformation of …

Structure and function of δ-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel

GM Nicholson, MJ Little, LC Birinyi-Strachan - Toxicon, 2004 - Elsevier
δ-Atracotoxins (δ-ACTX), isolated from the venom of Australian funnel-web spiders, are
responsible for the potentially lethal envenomation syndrome seen following funnel-web …

Hexapod Assassins' Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug Rhynocoris iracundus

N Rügen, TP Jenkins, N Wielsch, H Vogel, BF Hempel… - Biomedicines, 2021 - mdpi.com
Assassin bug venoms are potent and exert diverse biological functions, making them
potential biomedical goldmines. Besides feeding functions on arthropods, assassin bugs …