Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain various
biomolecules, including nucleic acids, proteins and lipids, and are manufactured and …

Simple Summary Cancer is the second leading cause of death in humans, and in 2020, 9.8
million cancer-related deaths were reported worldwide. In the last 20 years, it has become …

Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme
glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson's …

Sex-driven immune differences can affect tumor progression and the landscape of the tumor
microenvironment. Deeper understanding of these differences in males and females can …

Objectives Lung fibrosis is the leading cause of death in SSc, with no cure currently
available. Antifibrotic Endostatin (ES) production does not reach therapeutic levels in SSc …

Simple Summary Human cells can communicate with each other by releasing small packets
of protein called 'vesicles' that are absorbed by other cells nearby and at distant locations …

Extracellular vesicles (EVs) are small packages that contain proteins, lipids and nucleic
acids and are released by various cell types [1, 2]. With the discovery of EVs as mediators of …

Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell
communication, permitting cells to exchange proteins, lipids, and metabolites in varying …

Cancer cachexia (CC) is a debilitating syndrome that affects 50–80% of cancer patients,
varying in incidence by cancer type and significantly diminishing their quality of life. This …

Introduction Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and
treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with an …