Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they
can die through programmed cell death upon the stimulation of specific signalling pathways …

Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …

Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …

Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …

Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …

About 8% of our genome is composed of sequences with viral origin, namely human
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …

Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair
machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of …

The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic
acids represent a major class of pathogen signatures that can trigger robust immune …