Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Context.—Although many mesotheliomas are related to asbestos exposure, not all are, and
there is increasing information on other causes of mesothelioma. Objective.—To provide a …

This work reviews the bio-chemical mechanisms leading to adverse effects produced when
mineral fibres are inhaled and transported in the lungs from the perspective of a …

The BRCA1‐associated protein‐1 (BAP1) tumor predisposition syndrome (BAP1‐TPDS) is a
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …

A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or
malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through …

BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for
a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical …

Abstract BRCA1-associated protein-1 (BAP1) is a recognised tumour suppressor gene.
Germline BAP1 pathogenic/likely pathogenic variants are associated with predisposition to …

Summary BRCA1-associated protein 1 (BAP1) is a tumour suppressor gene frequently
inactivated in mesothelioma, rarely also in association with germline mutation. BAP1 …

Introduction Malignant pleural mesothelioma (MPM) is a highly aggressive disease with
limited therapeutic options. Histological subtype remains among the most reliable prognostic …

Importance Patients with germline mutations inBAP1may develop several flesh-colored
melanocyticBAP1–mutated atypical intradermal tumors (MBAITs). These tumors generally …