When apoptotic cells are not cleared in an efficient and timely manner, they progress to
secondary necrosis and lose their membrane integrity. This results in a leakage of …

Balancing cell survival and cell death is fundamental to development and homeostasis. Cell
death is regulated by multiple interconnected signaling pathways and molecular …

Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis
plays a major role in tumor necrosis. Although several key necroptosis regulators including …

Adoptive immunotherapy utilizing natural killer (NK) cells has demonstrated remarkable
efficacy in treating hematologic malignancies. However, its clinical intervention for solid …

Background Low-intensity transcranial focused ultrasound stimulation (TFUS) holds great
promise as a highly focal technique for transcranial stimulation even for deep brain areas …

M1 macrophages induce protective immunity against infection, but also contribute to
metabolic and inflammatory diseases. Here we show that the E3 ubiquitin ligase, MDM2 …

Background MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role
in tumor maintenance and survival and can act as a resistance factor to multiple anticancer …

Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is
engaged in triggering the rupture of cell plasma membrane. MLKL activation also leads to …

Sporadic apoptosis of tumour cells is a commonly observed feature of colorectal cancer
(CRC) and strongly correlates with adverse patient prognosis. The uptake of apoptotic cell …

Abstract The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions Project (www. toxpath. org/inhand. asp) is a joint initiative of the Societies of …