Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …

Nuclear shape and architecture influence gene localization, mechanotransduction,
transcription, and cell function. Abnormal nuclear morphology and protrusions termed …

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …

In vivo, the human genome functions as a complex, folded, three-dimensional chromatin
polymer. Understanding how the human genome is spatially organized and folded inside …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Progenitor cells differentiate into specialized cell types through coordinated expression of
lineage-specific genes and modification of complex chromatin configurations. We …

Lamins are components of the peripheral nuclear lamina and interact with heterochromatic
genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being …

Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree
of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 …