Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases

S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters

X Liu, C Luongo, Y Matsuoka… - Proceedings of the …, 2021 - National Acad Sciences
Single-dose vaccines with the ability to restrict SARS-CoV-2 replication in the respiratory
tract are needed for all age groups, aiding efforts toward control of COVID-19. We developed …

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine

LA Chang, E Phung, MC Crank, KM Morabito… - Science Translational …, 2022 - science.org
There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess
the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc …

Immunological lessons from respiratory syncytial virus vaccine development

TJ Ruckwardt, KM Morabito, BS Graham - Immunity, 2019 - cell.com
Respiratory syncytial virus (RSV) has eluded active vaccination efforts for more than five
decades and continues to cause substantial morbidity and mortality in infants, the …

Respiratory syncytial virus: the influence of serotype and genotype variability on clinical course of infection

S Vandini, C Biagi, M Lanari - International journal of molecular sciences, 2017 - mdpi.com
Respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae family,
Orthopneumovirus genus. It is the leading cause of acute bronchiolitis and one of the most …

Human respiratory syncytial virus: pathogenesis, immune responses, and current vaccine approaches

SA Taleb, AA Al Thani, K Al Ansari… - European Journal of …, 2018 - Springer
Respiratory syncytial virus continues to pose a serious threat to the pediatric populations
worldwide. With a genomic makeup of 15,200 nucleotides, the virus encodes for 11 proteins …

New insights on respiratory syncytial virus prevention

E Kopera, H Czajka, P Zapolnik, A Mazur - Vaccines, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is a well-known infant pathogen transmitted mainly by
droplets. It is a leading cause of upper respiratory tract infections in children, usually with a …

Hepatitis C virus vaccine design: focus on the humoral immune response

D Sepulveda-Crespo, S Resino, I Martinez - Journal of Biomedical Science, 2020 - Springer
Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis
C virus (HCV) infection remains a significant health problem. In 2016, the World Health …

Antibody-guided structure-based vaccines

PD Kwong, BJ DeKosky, JB Ulmer - Seminars in Immunology, 2020 - Elsevier
The vaccine field is pursuing diverse approaches to translate the molecular insights from
analyses of effective antibodies and their targeted epitopes into immunogens capable of …